• br Conclusions br Statement of authorship br Nonaneurysmal s

  2020-08-10

  

  Conclusions Statement of authorship Nonaneurysmal subarachnoid hemorrhage (NA-SAH) differs from aneurysmal subarachnoid hemorrhage (SAH) in both clinical course and outcome. In spite of many reports and case series since the first description in 1985, the etiology of NA-SAH remains uncertain

• PET CT static images of F CJ acquired

  2020-08-10

  

  PET/CT static images of F-CJ-042794 acquired at 1h p.i. from LNCaP tumour-bearing mice with/without co-injection of non-radioactive CJ-042794 (50μg) are shown in . The LNCaP tumours were clearly visualized in PET images with a moderate tumour-to-background contrast. High radioactivity accumulation w

• The importance of AAE in enhancing the survival

  2020-08-10

  

  The importance of AAE3 in enhancing the survival of plants and yeast when confronted with certain environmental stresses has been documented in recent reports. In response to biotic stress such as oxalate-secreting micro-organisms, AAE3 was found to reduce the inhibitory growth effects of the secret

• Although DP technologies are convenient for users to manufac

  2020-08-10

  

  Although 3DP technologies are convenient for users to manufacture devices automatically, the printing materials are inevitably limited by the manufacturers of 3D printers. Strategies are increasingly being developed to functionalize the raw printing materials or their printed devices with other phys

• Gupta et al have shown

  2020-08-10

  

  Gupta et al have shown that a genetic variant associated with the 5 vascular diseases (coronary artery disease, migraine, carotid artery dissection, fibro-muscular dysplasia, and hypertension) is a distal regulator of the ET-1 gene [30]. They found that a single nucleotide polymorphism (SNP) located

• br Materials and methods br

  2020-08-10

  

  Materials and methods Results Discussion Macrophages and dendritic cells respond to Toll-like receptor (TLR) ligands by upregulating CH25H expression [4], [5]. In the latter cell type TLR-dependent upregulation is mediated via a signalling pathway that involves NFκB and IFNβ secretion and c

• DDR was originally cloned by

  2020-08-08

  

  DDR1 was originally cloned by the group of Michele de Luca, at the time named TrkE. The Genoa-based research team identified the skin, and the keratinocytes in particular, as a major site of DDR1-binding activity [20]. DDR1 is also expressed in kidney, liver and lung (Fig. 2). The functional role of

• Activation of NF B induces hepatocyte apoptosis and autophag

  2020-08-08

  

  Activation of NF-κB induces hepatocyte apoptosis and autophagy during liver injury induced by IR [42,43]. The extent of apoptosis and autophagy were detected to better understand how L-THP pretreatment reduced liver injury during hepatic IR. Bax and Bcl-2 are members of the Bcl-2 protein family. Bax

• The H E staining and Nissl

  2020-08-08

  

  The H&E staining and Nissl staining results showed that damage to the pyramidal neurons in the CA1 and CA3 regions of the hippocampus were observed in the 50 mg/kg/day DBP group, accompanied by an absence of Nissl bodies, suggesting that DBP exposure can lead to pathological changes in the neurons o

• br Materials and methods br Results br Discussion

  2020-08-08

  

  Materials and methods Results Discussion The precise role of each of the EP receptor subtypes in the pathophysiology of the eye and other organs and their underlying mechanisms are poorly understood because of the interplay not only between EP receptors, but also between other chemical medi

• Conjugation of ubiquitin to substrates occurs at

  2020-08-07

  

  Conjugation of ubiquitin to substrates occurs at lysine residues of the substrate proteins. Lysine residues of the substrate can be modified with a single ubiquitin moiety (monoubiquitination) or chains of ubiquitin (polyubiquitination). Polyubiquitin chains are formed through the covalent binding o

• Concerns that DPP inhibitor can increase the risk of

  2020-08-07

  

  Concerns that DPP-4 inhibitor can increase the risk of 4E1RCat failure have been reinforced by the results of nonrandomized studies carried out in the community. Post-marketing analyses by the Food and Drug Administration have suggested a disproportionate reporting of adverse heart failure events am

• br Introduction Acylglycerol acyltransferases AGATs are

  2020-08-07

  

  Introduction Acylglycerol acyltransferases (AGATs) are predominantly responsible for triglyceride synthesis in the body, via two major pathways: the glycerol phosphate (GP) pathway (Kennedy, 1957) and the monoacylglycerol (MG) pathway (see Coleman and Lee, 2004, Yen et al., 2008). The final step

• The only reported synthesis of the aminobicyclic core of is

  2020-08-06

  

  The only reported synthesis of the aminobicyclic core of is based on bis-alkylation of a 4-amino-5,6-dihydroxypyrmidine with dibromoethane. The likelihood of poor regiocontrol/reactivity in utilizing such a transformation for the synthesis of compounds with a substituent on the dioxinyl ring led us

• Atg was first found to

  2020-08-06

  

  Atg4 was first found to physically interact with Atg8 in the yeast Saccharomyces cerevisiae in 1998 (Lang et al., 1998). There is only one single member of Atg4 proteins in yeast, and FDA-approved Drug Library mg of Atg4 impairs the autophagy process (Kirisako et al., 2000). In mammals, there are f

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