• The following are the supplementary data related to this

  2020-08-06

  

  The following are the supplementary data related to this article. Transparency document CDKs and their Regulation CDKs are multifunctional enzymes that can modify various protein substrates involved in the cell cycle. Human cells have 13 CDKs that interact with at least 29 cyclins or cyclin-r

• Heterozygous SERT knockout showed an

  2020-08-06

  

  Heterozygous SERT knockout showed an intermediate level of FPS in Experiment 1, but normal FPS in Experiment 4, Experiment 5. Apparently, high redundancy exists in the involvement of SERT in normal fear acquisition, as availability of only 60% of normal SERT levels (Homberg et al., 2007a) is still s

• Despite the evidence accumulated on the involvement of ETs

  2020-08-06

  

  Despite the evidence accumulated on the involvement of ETs and their receptors in many pain states, their potential contribution to nociception following SCI has not yet been investigated. Hence, the present study was designed to assess the roles exerted by ETAR and ETBR in neuropathic pain after SC

• The ETR family contains two

  2020-08-05

  

  The ETR family contains two subtypes, ETA and ETB, that are expressed at similar levels in the SP 141 [[4], [5], [6], [7]]. ETR subtypes are able to regulate multiple signalling pathways including phospholipase D, phospholipase A2, Na+/H+ exchangers, cAMP and cGMP production, mitogen activated prot

• The Ub E consists of four

  2020-08-05

  

  The Ub-E1 consists of four building blocks: First, the adenylation domains composed of two MoeB/ThiF-homology motifs (hereafter, IAD and AAD, for “inactive” and “active” adenylation domain, respectively), the latter of which binds ATP and Ub (Lake et al., 2001, Lois and Lima, 2005, Walden et al., 20

• The development and physiology of cartilage

  2020-08-05

  

  The development and physiology of cartilage and bones are highly similar in mammals and teleosts validating the zebrafish as a reliable vertebrate model in this field [22]. Expression of genes and the molecular pathways involved in the endochondral ossification are well conserved. For instance, as i

• Progesterone may play a role in mediating anxiety

  2020-08-05

  

  Progesterone may play a role in mediating anxiety, impulsivity, fear and motor responses, and can produce other non-behavioral effects that are important when considering treatment options in a clinical population. As well, estrogen may be mediating effects on burying and aversive responses to novel

• The NMT data showed greater Na efflux and

  2020-08-04

  

  The NMT data showed greater Na+ efflux and H+ influx in the roots of transgenic plants compared with the WT after salt stress (Fig. 12), which indicated stronger activity of the Na+/H+ antiporter salt overly sensitive 1(SOS1) in the transgenic Arabidopsis (Jian, 2009, Sun et al., 2009). The possible

• In the case of women and men diagnosed

  2020-08-04

  

  In the case of women and men diagnosed with APD, no increase in the IL-6 level was found as compared with the control group. However, such an increase, which was double, was observed both in the group of women and men with APD and PTSD versus the group of women and men suffering from APD alone. Thi

• The cervix undergoes complex changes during the normal

  2020-08-04

  

  The casr undergoes complex changes during the normal estrous cycle, pregnancy and parturition (Nallasamy and Mahendroo, 2017). During estrus in the ewe and mouse, there is slight relaxation and dilation which is partly due to the reorganization of collagen bundles and fibers that disperse and “softe

• Eph receptors are overexpressed in various

  2020-08-04

  

  Eph receptors are overexpressed in various tumor types, suggesting a role of the Eph receptors in tumor progression [12]. Up-regulation of EphrinB2 has been reported in melanomas. In the present investigation, we found that staining intensities of EphrinB2 in arterial and EphB4 in venous endothelium

• Our previous studies have demonstrated that the DDR discoidi

  2020-08-04

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• br Conclusion Conventional surgical excision of

  2020-08-04

  

  Conclusion Conventional surgical excision of the tumoral lesions is the primer therapy for the BCC. Recurrence rates are significantly higher for surgical margin positive lesions that also creates challenges for the surgeons on obtaining best cosmetic and oncologic results. In our study, EGFR Ac

• DNA PK plays an essential role in protecting genome

  2020-08-04

  

  DNA-PK plays an essential role in protecting genome stability during the events of double-strand break (DSB), and considered crucial component in NHEJ repair pathway. Where, in such pathway, DNA-PKcs is recruited at the site of DSB by the Ku protein, which in turn recruits and phosphorylates a nucle

• cyclic amp function DNA ligase IV contains a conserved

  2020-08-04

  

  DNA ligase IV contains a conserved ligase domain at its N-terminus and a tandem BRCT domain at its C-terminus (Fig. 1a) [7]. Interaction with Xrcc4 requires the region between the BRCT domains and likely part of the BRCT domain [8], [9]. The DNA ligase IV/Xrcc4 complex is large and its crystal struc

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